Lion-Paw: Lymphadenectomy In Ovarian Neoplasm-Pleasure Ability Of Women-Prospective Substudy Of The Randomized Multicenter Lion Study.

5575Background: There is limited information regarding the impact of radical surgery including pelvic and para-aortic lymphadenectomy (LNE) and subsequent chemotherapy on sexuality in patients (pts.) with advanced ovarian cancer (AOC). We addressed this question within the prospectively randomized LION trial, evaluating the role of LNE in AOC. Methods: The Sexual Activity Questionnaire (SAQ) was used to assess sexual function in terms of its subscales activity, pleasure, and discomfort. Additionally we added the “orgasm” subscale from the Female Sexual Function Index. The questionnaire was administered together with the EORTC QLQ-C30 questionnaire at baseline before surgery, after 6, 12 and 24 months. Primary endpoint was changes in sexual function. Results: 495 pts. received the questionnaires. 254 pts. responded at baseline (55 sexually active, 182 sexually inactive,17 data not available (na)), 55 at 6 months, 139 at 12 and 81 at 24 months (22 active, 56 inactive, 3 data na). Median age was 60.5 years (...