Abstract 14527: Temporal Changes in Cardiac Troponin I and Risk ofCardiovascular Events in the General Population: The Nord-Trøndelag Health Study

Introduction: Concentrations of cardiac troponin are strongly associated with risk of heart failure (HF), myocardial infarction (MI), and cardiovascular death (CVD) in the general population. Temporal changes in cardiac troponin T have also been associated with increased cardiovascular risk, but the corresponding association for cardiac troponin I (cTnI) remains unclear. Hypothesis: Temporal changes in cTnI are associated with risk of HF, MI, and CVD in the general population. Methods: We measured cTnI with a high-sensitivity assay in 4803 participants of the prospective observational HUNT Study, at study visit 2 (1995-97) and visit 3 (2006-2008). All subjects were free from known cardiovascular disease at baseline. Change in cTnI was modeled as change of u003c50%, increase of ≥50%, or decrease of ≥50% from concentrations at visit 2. A composite endpoint of first admission for MI or HF, or CVD was generated. Results: Participants with relative decrease in cTnI were more frequently younger and female, and had ...