The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia

•Oxidative damage is a key feature of AD, the major cause of age-related dementia.•TRPM2 channel is part of a positive feedback loop for Aβ/ROS-induced neuronal death.•TRPM2 channel is required for Aβ-induced microglial cell-mediated neuroinflammation.•TRPM2 channel in endothelial cell mediates Aβ-induced neurovascular dysfunction.•TRPM2 channel has emerged as a novel drug target for intervening AD and dementia.