An Effective Heterogeneous Copper Catalyst System for C–N Coupling and Its Application in the Preparation of 2-Methyl-4-methoxydiphenylamine (MMDPA)
SYNTHESIS-STUTTGART(2018)
摘要
A ligand-recyclable, environmentally benign heterogeneous catalyst system composed of Cut arid polystyrene-supported N(-(4-aminomethyl)naphthalen-1-yl)-N(-phenyl-1H-pyrrole-2-carbohydrazide (PSAP) has been established for Ullmann type C-N coupling based on the homogeneous catalyst system N',N'-diphenyl-1H-pyrrole-2-carbohydrazide/Cul. This heterogeneous catalyst system maintained the catalytic effectiveness of the homogeneous catalyst. A variety of functionalized aryl bromides can be efficiently aminated with aryl amines and aliphatic amines with high selectivity for amines over alcohols. Moreover, a practical application of this catalyst system to promote the reaction of commercially available 4-methoxy-2-methylaniline and bromobenzene in 10 mmol scale, provided 2-methyl-4-methoxydiphenyl-amine (MMDPA) with 93% yield with the merit of the approach being simple operation for work-up and purification.
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关键词
heterogeneous catalysis,copper catalysis,C-N coupling,recyclability,2-methyl-4-methoxydiphenylamine (MMDPA)
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