Normal saline versus Normosol™-R in sepsis resuscitation: A retrospective cohort study:

ObjectiveTo determine the effect of Normosol™-R as compared to normal saline on the outcomes of acute kidney injury and the need for renal replacement therapy in the resuscitation phase of sepsis.DesignOur study is a retrospective before-and-after cohort study.SettingThe study occurred at a 700-bed tertiary academic level 1-trauma center.PatientsA total of 1218 patients were enrolled through emergency department admissions. The normal saline (before) cohort was defined as the dates between 1 March and 30 September 2014 and the Normosol™-R (after) cohort was assessed from 1 March to 30 September 2015.InterventionsNone.Measurements and main resultsIntravenous fluid volumes received during the first 24 h, 72 h, and total hospital stays were compared. Sodium, chloride, potassium, and bicarbonate levels at 72 h were also compared. The medical coded diagnosis of acute kidney failure, need for renal replacement therapy, hospital LOS, ICU admission, ICU LOS, in-hospital mortality, and need for mechanical ventilat...