Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A−C and their derivatives
Tetrahedron Letters（2018）
Abstract
•Structure-activity relationship of geranyl resorcylates derived from Hericium erinaceum was investigated.•Four natural products and five derivatives were synthesized.•Neuroprotective activities against endoplasmic reticulum (ER) stress-dependent cell death were evaluated.•Synthetic derivatives exhibited higher neuroprotective activities than natural products.
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Key words
Geranyl resorcylate,Total synthesis,Structure-activity relationship,Endoplasmic reticulum stress,Neuroprotective agent
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