Cancer-associated fibroblasts in tumor microenvironment – Accomplices in tumor malignancy
Cellular Immunology（2019）
Abstract
•CAF is the major stromal cell type in many tumor microenvironments.•CAFs enact field cancerization by promoting extratumoral oxidative stress.•CAFs interact with tumor-infiltrating immune cells to promote cancer progression.•CAFs can influence the directionality and migration of cancer cells.•Targeting different subpopulations of CAFs led to unexpected cancer outcome.
MoreTranslated text
Key words
Cancer-associated fibroblasts,Somatic Mutation Theory,Tissue Organization Field Theory,Field cancerization,Tumor microenvironment,Metastasis
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined