Противоопухолевые эффекты сочетанного применения витаминов В1, В6 и В12

Vitamin B complex is widely used therapeutically and prophylactically in neurology; they are often prescribed for long-term treatment (for weeks and months). In this connection, it is important to comprehensively estimate the feasibility and safety of its use, especially at high (therapeutic) doses. The paper discusses the potential anticancer effects of vitamin B complex. Objective: to evaluate the effect of thiamine disulfide, pyridoxine hydrochloride, and cyanocobalamin (neurobion 110 mg/kg/day) on the growth and metastatic spread of malignant tumors in mice. Material and methods. Experiments were carried out in 25 F1 hybrid male mice (aged 2.5–3 months; body weight, 23–26 g). Transplantable Lewis lung epidermoid carcinoma (LLC) was used as a tumor model Results and discussion. The experimental animals tolerated the drug well; there were no symptoms of intoxication. The drugu0027s effects lasting up to 21 days of LLC development were accompanied by a growing trend towards tumor growth inhibition by 10–20% (p=0.059). Conclusion. After subchronic intragastric administration of B12 at a daily dose of 110 mg/kg to tumor-bearing animals, there is a steady tendency to LLC growth inhibition. No antimetastatic activity was found.