Network Analysis Of Micrornas Genes And Their Regulation In Ewing'S Sarcoma

Experimentally validated data of the genes, microRNAs (miRNAs) and transcription factors (TFs) that affect EWS can be found in many literatures and databases. However, majority of them are in scattered form. The systematic regulatory mechanism has yet to be revealed. We constructed three regulatory networks hierarchically, including differentially expressed network, related network and global network. The differentially expressed network can be used as a faulty map of EWS. If the errors can be corrected, the cancer may be prevented and even cured in theory. Next, we compared their similarities and differences, a number of significant pathways, some self-adaptation associations and circle-regulations were highlighted. The differentially expressed network illuminated the pathogenesis of EWS. In addition, the related network further delineates the regulatory mechanism related with EWS. This paper systematically presented the regulatory mechanism of EWS and supplied gene therapy researchers with theoretical basis to concentrate on crucial genes and miRNAs.