1712 ‘Less contented as a person’: preliminary data from the lgi1-qol study

ObjectiveTo describe the long-term cognitive, neuropsychiatric and quality of life (QOL) outcomes in LGI1-antibody encephalitis.Methods42 patients, forming the initial cohort of the LGI1-QoL study, have undergone detailed evaluation. Preliminary results of the Addenbrooke’s Cognitive Examination – Revised (ACE-R), Hospital Anxiety and Depression Scale (HADS), EQ-5D-5L and Life Satisfaction Questionnaire (LSQ) are presented.ResultsPatients (29 male) aged 44–86 were assessed at a median of four years post-illness onset (range 0.5–15 years). Mean ACE-R was 90 (range 68–99); there were no differences with length of follow-up. Depression or anxiety (HADS >7) were found in 15% and 28% respectively, with a modest tendency to improve over time. Subjective patient health ratings, via the EQ-5D-5L, were worse post than pre-illness, most marked at younger ages, while the LSQ showed significant decline in the domains of life as a whole, leisure, vocation, sexual life and contacts with friends, with the most significant change (p=<0.0001) in vocation and, surprisingly, sexual life. The localisation of the sexual dysfunction was explored with imaging and immunohistochemical studies suggesting localisation to the amygdala.ConclusionsThere are notable effects on health and QOL several years post-LGI1-antibody encephalitis. Future work should focus on early interventions to improve outcomes.