Secreted App Alpha And App Beta In Cerebrospinal Fluid Correlate With Phosphorylated Tau And Are Potentially Useful Biomarkers For Early Diagnosis Of Dementia Disorders

W. Araki, Y. Araki,K. Hattori, K. Kazutomi,Y. Yokoi,H. Takano, M. Sakata,S. Yoshida,T. Tsukamoto,M. Murata,Y. Saito,H. Kunugi,Y.I. Goto,U. Nagaoka,M. Nagao,T. Komori,K. Ishii, H. Tachimori,H. Matsuda,H. Mizusawa

JOURNAL OF THE NEUROLOGICAL SCIENCES（2017）

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摘要

Background: Because secreted amyloid precursor protein (APP)-β (sAPPβ) and sAPPα possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorders, including AD and mild cognitive impairment (MCI) due to AD. However, controversial results have been reported regarding their usefulness as diagnostic biomarkers.

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关键词

appβ,cerebrospinal fluid correlate,cerebrospinal fluid,useful biomarkers,tau

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