P2.01-069 Erythron Reaction Shows High Malignant Tumor Process in Lung Cancer Patients: Topic: Marker for Prognosis

It is known that in many cancers recorded violations in the erythroid hematopoiesis. In order to determine these deviations predicative of significance in the assessment and prediction of malignancy conducted studies on patients with lung cancer. The study group included 28 men aged 45 to 72 years and three women aged 45 - 50 years; the tumor stages: T1N0M0 - 1; T2N0M0 - 10; T2N1Mh -6; T2N2M0 -4; T3N0M0 - 6; T3N0M1 - 2; T3N2M0 - 2. All patients underwent specific anticancer therapy. As a comparison group used clinically healthy people of the same sex and age. Characteristics of red blood was obtained for clinical analysis using an automated hematology analyzer. On the kinetics of acid hemolysis of red blood cells (Gitelzon test) evaluated their resistance and the volume fraction of young erythrocytes. By enzyme immunoassay the concentration of hypoxia-induced factor 1 α in serum using commercial kits Human hypoxia-inducible factor 1α («Cusabio», France). As an example, the data obtained during the examination preoperatively patient 50 years old, diagnosed with lung cancer at stage T1N0M0. It was registered a significant increase in serum concentrations of HIF 1 α, exceeding the number of red blood cells and hemoglobin concentration of peripheral blood when compared with reference values of parameters. Against this background, it increases resistance to acid lyse erythrocytes, and the volume fraction of young erythrocytes increased to 46% to 16% of clinically healthy individuals. Stimulation of erythroid hematopoiesis additionally recorded and release into the blood reticulocytes with a low degree of maturity. Additionally, peripheral blood decreased platelet count, and the postoperative period was complicated by bleeding without an identified source. Reaction red germ hematopoiesis and coagulation in this patient may be due to the influence of factors released into the blood tumor. These results confirm the fact that tumors are able to exert influence on the state of a number of functional systems, and thus are able to exacerbate the underlying disease. A pooled analysis of hematological and biochemical parameters of blood can yield information on the formation of an aggressive tumor phenotype.