Cyclodextrine-nanoencapsulation of niclosamide: Water solubility and meaningful enhancement of visible-light—Mediated sensitized photodegradation of the drug

Eduardo Gatica,José Natera,Adriana Pajares,Carolina Gambetta,Matías I. Sancho,Walter A. Massad,Norman A. García

Journal of Photochemistry and Photobiology A: Chemistry（2017）

引用 6|浏览11

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摘要

•Niclosamide (NSD) forms a 1:2 aqueous complex with 2-hydrxypropyl-β-cyclodextrin.•Complexed NSD is oxidized through a Riboflavin-photosensitized process.•The photodecomposition process is much more efficient than in homogeneous medium.•Photodegradation is affected by dynamic and electrostatic factors and pH changes.

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关键词

Cyclodextrin encapsulation,Niclosamide,Photooxidation,Photosensitization,Reactive oxygen species,Riboflavin

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