Modified Julia olefination and α aminoxylation reactions mediated convergent synthesis of 1α, 24 (R)-dihydroxyvitamin D3 (tacalcitol)
Tetrahedron Letters(2017)
Abstract
•A convergent synthesis of tacalcitol.•Cheap and commercially available starting material.•Vitamin D analogue for the treatment of psoriasis.
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Key words
Calcitriol,Vitamin D,α aminoxylation,Julia-Kocienski olefination,Tacalcitol
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