Facile Synthesis Of Novel Hybrid Poss Biomolecules Via "Click" Reactions

A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield (82-90%). The X-ray crystal structure revealed intra-and intermolecular hydrogen bonding between the amide groups of the arms. Hybrid biomaterials were synthesised in nearly quantitative yields via a click reaction with (i) azido-N-Fmoc-norleucine and (ii) 3'-azido-3'-deoxythymidine.