ИНТЕГРИРОВАННЫЙ БИОМАРКЕР: ВОЗМОЖНОСТИ НЕИНВАЗИВНОЙ ДИАГНОСТИКИ КОРОНАРНОГО АТЕРОСКЛЕРОЗА

Aim. With the multimarker approach, to investigate and implement an integrative biomarker for non-invasive risk assessment of the presence and severity of coronary atherosclerosis. Material and methods. Totally, 205 consecutive patients included, age 18 and older, mean age 62,8±9,0 y., admitted and investigated in-patient at National Research Center for Preventive Medicine of the Ministry of Health in 2011-2013, underwent diagnostic coronary arteriography (CG) and duplex carotid scanning. Localization and grade of coronary atherosclerosis were assessed with the score Gensini (GS). Results. The analysis was done in 3 groups: no coronary atherosclerosis (GS =0), with coronary atherosclerosis of any grade (GS u003e0), and severe (GS ≥35). Based in the preliminary analysis of mathemathical models that included visual and biochemical markers, the most siginificant were selected that have been included into the integrated biomarker. Value of i-BIO u003e4 points with sensitivity 87,9% makes it to reveal coronary atherosclerosis patients, when i-BIO u003e9, with specificity 79,8%, makes it to rule out the persons with no coronary atherosclerosis. Conclusion. The invented complex parameter i-BIO might be regarded as a novel integrative biomarker of coronary atherosclerosis and its severity grade.