RINOSSINUSITE FÚNGICA NÃO ASPERGILAR EM UM HOSPITAL TERCIÁRIO E RELATO DO PRIMEIRO CASO DE INFECCÃO HUMANA POR TRICHODERMA ASPERELLUM

We describe 27 cases of fungal rhinosinusitis, which were caused by agents other than Aspergillus, diagnosed at our institution during a 24-year period. Particular focus was on defining the causal fungi and the predisposing factors. Fungal cultures were obtained from 20 cases and there was no growth in seven cases. Classification of mycotic disease of the nose and paranasal sinuses as invasive and noninvasive is based on clinical, radiological, and histopathological factors. The most common pathogens were Histoplasma capsulatum (n=4), Scedosporium apiospermum (n=2), Alternaria alternata (n=2), Schizophyllum commune (n=2), Pseudallescheria boydii (n=1), Penicillium sp. (n=1), Lichtheimia (Absidia) corymbifera (n=1), Xylaria enteroleuca (n=1), Trichoderma asperellum (n=1), T. harzianum (n=1), T. viride (n=1), Fusarium solani (n=1), Cladosporium sp. (n=1), and Cryptococcus neoformans (n=1). From the ones that revealed no growth, four were classified as hyalohyphomycosis and three were mucormycosis by the histopathological findings. In addition, we describe the first welldocumented case of rhinosinusitis and human infection by T. asperellum.