Development of sesamin-loaded solid dispersion with α-glycosylated stevia for improving physicochemical and nutraceutical properties

Hideyuki Sato,Asako Aoki,Aiko Tabata,Kazunori Kadota,Yuichi Tozuka,Yoshiki Seto,Satomi Onoue

Journal of Functional Foods（2017）

引用 12|浏览1

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摘要

•Alpha-glycosylated stevia improved the aqueous solubility of sesamin (SES).•SES-loaded solid dispersion (SD) system markedly enhanced oral absorption of SES.•Orally-dosed SES-loaded SD suppressed drug-induced photodermatosis in rats.•Novel SD system might be promising to enhance the nutraceutical potential of SES.

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关键词

ANOVA,DSC,ESI,Hesperidin-G,PLM,RH,Rutin-G,SD,SEM,SES,Stevia-G,TF,UPLC,UV,PXRD

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