Influencia del nadir de PSA y el tiempo a nadir en el periodo libre de enfermedad (ple) del carcinoma prostático localizado tratado con irradiación radical

Objective: To evaluate the prognostic significance of PSA nadir (nPSA) and the time to nadir in disease free of recurrence (DFR) in localized carcinoma of prostate treated with radical radiotherapy (RTR). Material and methods: From October 1984 to December 1998, 86 patients have been treated with prostate carcinoma. It was considered of Low risk those patients with PSA 5 10 ng/ml, Gleason = 6 or stage TI-T2. Moderate risk: those with one elevated of the three parameters. High risk: two or more parameters. The treatment was carried out in a lineal accelerator using photons of 15MV, with standard technique and frationation, administering a median dose of 66Gy (58-75Gy). It was defined disease free of recurrence (DFR),the time to clinical PSA or biochemical failure. This one was defined as the time starting from the date of nadir PSA to the second consecutive increase of PSA value after three separate serial measurements separated for at least one month. Results: The median of initial PSA value was of 16