17α-ethynilestradiol and tributyltin mixtures modulates the expression of NER and p53 DNA repair pathways in male zebrafish gonads and disrupt offspring embryonic development
Ecological Indicators(2018)
摘要
•Parental exposure to EE2 and EE2 plus TBT impairs zebrafish embryonic development.•EE2 and TBT, single and combined, modulate key DNA repair genes.•p53 gene expression in male gonads reflects embryonic development disruption data.•Mixtures of the selected compounds produce chiefly unpredictable effects.
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关键词
17α-Ethinylestradiol,Tributyltin,Mixtures,Embryonic development,NER,p53
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