Targeting Leishmania amazonensis amastigotes through macrophage internalisation of a hydroxymethylnitrofurazone nanostructured polymeric system
International Journal of Antimicrobial Agents(2017)
Abstract
•NFOH poly (n-butyl cyanoacrylate) nanoparticle encapsulation efficiency was 64.47 ± 0.43%.•The CC50 was 122.3 µM for PBCA–NFOH-NPs, 142.9 µM for unloaded NPs and 237.0 µM for free NFOH.•PBCA–NFOH-NPs showed IC50 values of 4.9 µM and 0.33 µM for L. amazonensis promastigotes and amastigotes, respectively.•The selectivity index was 370.6 for PBCA–NFOH-NPs, which was 49-fold higher than free NFOH (7.6).•The activity of PBCA–NFOH-NPs revealed the potential application for targeted delivery to macrophages.
MoreTranslated text
Key words
Hydroxymethylnitrofurazone,Poly (n-butyl cyanoacrylate),Leishmaniasis,Drug delivery,Polymeric nanoparticles,Dextran
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined