331 Il-1Β and il-6 are highly expressed in rf+ige+ systemic lupus erythematous subtype

Background and aims Systemic lupus erythematous (SLE) is anautoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. To better categorise SLE subtypes we determined the dominant cytokines based on RF+IgE+ (both RF and IgE were positive ) familial SLE. Methods RF, IgE and multiple cytokines (i.e., IL-1β, IL-6, IL-8, IL-10, IL-17, IFN–γ, IP-10, MCP-1 andMIP-1β) were measured in sera of familial SLE (n=3),non-inherited SLE (n=108) and healthy controls (n=80). Results Three SLE patients in family and 5 out of 108 non-inherited patients featured with RF+IgE+. These RF+IgE+SLE patients expressed significantly higher levels of IL-1β and IL-6 than the other SLE patients (p 2 =0.583,p=0.027; r 2 =0.847,p=0.001). Conclusions Both IL-1β and IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype.