Ruthenium(ii)-catalyzed C–H alkenylation/annulation cascade for the rapid synthesis of benzoimidazoisoindoles
Organic Chemistry Frontiers(2017)
Abstract
An efficient one pot synthesis of benzimidazole-fused isoindoles from 2-arylbenzimidazole and readily available conjugated alkenes has been explored. The developed domino strategy involved the ruthenium-catalyzed formation of two distinct C-C and C-N bonds and one new five-membered ring to afford a polycyclic molecule. The rapid and base-free reaction conditions and the broader substrate scope are salient features of this novel protocol. The ruthenium-catalyzed tandem reaction provides a direct tool for the easy and rapid access to a new benzoimidazoisoindole scaffold.
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Key words
rapid synthesis
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