The common genetic variants in IL - 1Β and IL - 1RN may have no predisposition to alcoholic liver disease: A meta-analysis

Abstract Background Interleukin-1β (IL-1β) has been demonstrated to play critical roles in the development of alcoholic liver disease (ALD). However, the association studies about functional polymorphisms of interleukin - 1β gene ( IL - 1Β ) and interleukin-1 receptor antagonist gene ( IL - 1RN ) and individual susceptibility to ALD produced conflicting results. Thus, a systematic review and meta-analysis was performed to investigate the associations between IL - 1Β and IL1RN polymorphisms and ALD risks. Methods Relevant studies were retrieved from six database including PubMed, Web of Science, Scopus, China Biology Medical literature database (CBM), Database of Chinese Scientific and Technical Periodicals (VIP), and Wanfang Data. Pooled odds ratio (OR) and 95% confidence interval (95%CI) were calculated by random-effects model. Results A total of 10 studies (including 825 ALD patients, 470 alcoholics without ALD and 743 health controls) were identified and included in the meta-analysis. The combined results showed that there were no significant associations between IL - 1Β (−  511C  u003e  T and +  3953T  u003e  C ) polymorphisms and ALD susceptibility, or between IL - 1RN VNTR polymorphism and ALD susceptibility. Moderate to higher heterogeneity was detected in most comparisons. No obvious publication bias was observed in all the genetic models. Conclusion The common genetic variants in IL - 1Β and IL - 1RN may have no predisposition to ALD. Large and well-designed epidemiological studies are needed to confirm these results.