Effect of Clinofibrate (Lipoclin R ) on Serum Cholesterol Level in Hypercholesterolemic Diabetics: ―多施設による検討―

Diabetes mellitus is one of the atherogenic diseases. We should improve not only the derangement of glucose metabolism but also the hypercholesterolemia in diabetics. Clinofibrate (LipoclinR) is clinically useful in hypercholesterolemia. In order to evaluate the effect of this drug on serum cholesterol level, we studied 106 hypercholesterolemic diabetics.Clinofibrate (600mg/day) was orally administered to each patient. Their serum lipids were measured before and every 4 weeks for 24 weeks after administration of this drug.The results were that (1) serum total cholesterol levels were significantly (p<0.001) decreased after Clinofibrate administration, (2) this decrease was observed not only in well controlled diabetics (fasting blood glucose, FBG<120mg/dl) but also in fairly controlled diabetics (FBG 120-179mg/dl) under stable condition, and (3) this decrease was found in the case with persistent proteinuria.In conclusion, this drug is useful to decrease serum cholesterol level in hypercholesterolemic diabetics.