A Clinical Prognostic Model To Predict Survival And Efficacy In Advanced Or Metastatic Non-Small Cell Lung Cancer Patients Who Received First-Line Chemotherapy: A Retrospective Analysis Of 236 Patients In Northeast China.

e19004 Background: This study was aimed to build a prognostic model for survival and predict efficacy in patients undergoing first-line chemotherapy in advanced or metastatic non-small cell lung cancer. Methods: Sixteen pretreatment clinical and biological variables were analyzed in 236 NSCLC patients who received first-line chemotherapy in our hospital. The prognostic model was calculated according to the results of multivariate Cox model, and the survival in different score groups were estimated by the Kaplan-Meier method and Long-rank tests. Results: Sixteen factors (smoking history, performance status, gender, disease stage, histological type, LDH, fibrinogen, WBC count, granulocyte count, lymphocyte count, hemoglobin, albumin, FBG, PLT, TP, β2-MG) were analyzed in univariate model for overall survival. The result showed PS=1 (HR=1.85, p 4.85×109/L (median) (HR=1.65, p=0.004) and increased PLT (HR=1.78,...