New Standards in Orthotopic Cardiac Xenotransplantation of Multitransgenic Pig Hearts Preserved with “Steens” Cold Blood Cardioplegia Perfusion in a Pig-to-Baboon Model with CD40mAb or CD40L Costimulation Blockade

P. Brenner,T. Mayr, B. Reichart,S. Guethoff,S. Buchholz,A. Dashkevich,S. Michel,I. Lutzmann,F. Werner,A. Bauer,N. Klymiuk,E. Wolf,K. Reimann,M. Mohiuddin,W. Hermanns,D. Ayares,C. McGregor,S. Steen,J.M. Abicht

Thoracic and Cardiovascular Surgeon（2017）

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Abstract

Aim: To achieve a constant preclinical long-term survival in a life-supporting cardiac xenotransplantation model (pig-to-baboon), a nontoxic immunosuppression based on CD40/CD40L co-stimulation blockade was used and an improvement of primary graft function with non-ischemic myocardial preservation in a group G2.

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Key words

orthotopic cardiac xenotransplantation,multitransgenic pig hearts,cold blood cardioplegia perfusion,pig-to-baboon

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