Hyperuricemia in Patients with Chronic Renal Failure in the General Hospital of National Reference of N’Djamena (Chad)

Introduction:Hyperuricemia is defined as a level of serum uric acid greater than or equal to70 mg/l (420 μmol/l)in men and60 mg/l (360 μmol/l) in women. Several studies have shown that it is a riskfactor or a factor of progression of chronic kidney disease. Recent experimentaland epidemiological data correlate the association of hyperuricemia withchronic kidney disease (CKD), arterial hypertension and cardiovasculardiseases, thus raising the question of the usefulness of therapeutics in theprevention of renal diseases. The objective of this study is to seek a linkbetween chronic kidney disease and hyperuricemia. Materials and Methods: Thisis a descriptive and analytical study conducted at hemodialysis unit andcardiology service of General Hospital of National reference of N’Djamena(Chad) from 1th January to 1th October 2013 (10 months).We included all chronic kidney disease patients hospitalized in hemodialysisunit and cardiology service who presented associated hyperuricemia. Results:There were 712 CKD patients who were hospitalized. Among them, there were 108patients who were included in the study and who had hyperuricemia as aprevalence of 15.20%. The average age of patients was 35.5 years and the sexratio was 3/1. The age group between 40 to 60 years represented 54.6%. Therewere 41.7% of traders. Hypertensive patients accounted for 49.1%; associationof diabetes and hypertension was noted in 12.90%. Renal insufficiency wasmoderate in 43.5% of patients. Hyperuricemia was present in more than 90% of patients.Profession, age, hematuria, proteinuria and hypertension were statistically positively relatedto hyperuricemia. Treatment consisted of prescribing allopurinol in 84% ofpatients. In more than 11% of patients the progression was unfavorable. Conclusion:The implication of hyperuricemia in chronic kidney disease has been proved inseveral recent studies. However, randomized studies at very long scales have tobe carried out to conclude from its real impact on the prevention and treatmentof chronic kidney disease.