Application of Rose and Wright’s algorithm in the diagnosis of lacrimal gland masses: a study of 93 cases

Abstract Objective To investigate the application of Rose and Wrightu0027s algorithm in diagnosing lacrimal gland masses. Design Retrospective observational cases series. Participants A total of 93 consecutive patients with primary masses within the orbital lobe of the lacrimal gland were reviewed. Methods Before treatment, patientsu0027 detailed history was collected verbally and all patients underwent image examination (computed tomography and magnetic resonance imaging). The clinical and radiological features of every patient were evaluated by experienced orbital surgeons. Based on Rose and Wrightu0027s criteria, patients were scored and then treated using surgery with radiotherapy and/or chemotherapy. The final diagnoses were based on the histopathologic results. Based on the histopathologic diagnosis, the data from Rose and Wrightu0027s algorithm were evaluated. Results The accuracy of Rose and Wrightu0027s algorithm for benign and malignant tumour diagnoses was 75% and 50%, respectively. The diagnostic sensitivity, specificity, and accuracy of Rose and Wrightu0027s algorithm were 64%, 93%, and 86%, respectively. The algorithm demonstrated significant accuracy in the clinicoradiological criterion in differentiating between benign tumours and malignant tumours ( p Conclusions Rose and Wrightu0027s algorithm has great advantages in distinguishing benign from malignant tumours within the orbital lobe of the lacrimal gland. However, the algorithm should be used with great caution because of its low diagnostic sensitivity for malignant tumours.