The DNA-binding box of human SPARTAN contributes to the targeting of Polη to DNA damage sites

Agnes Toth,Lili Hegedus,Szilvia Juhasz,Lajos Haracska,Peter Burkovics

DNA Repair（2017）

引用 13|浏览6

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摘要

•SPARTAN binds ssDNA and fork-like DNA structures.•The DNA binding motif of SPARTAN maps next to the SprT domain.•The DNA binding by SPARTAN is important for Polη targeting to the stalled replication fork.

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关键词

SPARTAN,Translesion synthesis,DNA polymerase eta,Damage tolerance

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