Interferon-γ in Salmonella pathogenesis: New tricks for an old dog

•IFN-γ is important in controlling Salmonella replication and spread in phagocytes.•IFN-γ induces expression of Guanylate Binding Proteins (GBPs).•GBPs promote Salmonella clearance by rupturing its protective intracellular vacuole.•Salmonella thus exposed triggers pyroptosis of the host phagocyte.