4-O-galloylalbiflorin discovered from Paeonia lactiflora Pall. is a potential β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor
Journal of Functional Foods(2016)
Abstract
•4-O-galloylalbiflorin (4-O-GA) was discovered as a novel BACE1 inhibitor.•4-O-GA could selectively inhibit the activity of BACE1 with IC50 5.11 ± 0.73 µM.•4-O-GA could decrease Aβ1–40 and Aβ1–42 levels in SH-SY5Y cells.•Docking results showed 4-O-GA can well bind with key residues of BACE1.
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Key words
Alzheimer's disease (AD),β-secretase (BACE1),β-amyloid peptide,Paeonia lactiflora Pall,4-O-galloylalbiflorin,Docking
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