HYPERTENSION IS ASSOCIATED WITH SIGNIFICANT RECRUITMENT OF PRO-INFLAMMATORY SPLENIC MONOCYTES/MACROPHAGES TO THE HEART
Canadian Journal of Cardiology(2016)
Abstract
Monocytes/macrophages are increasingly recognized as important regulators of inflammatory injury and scarring in the heart, termed myocardial fibrosis. However, our understanding of the early changes in monocytes/macrophages between storage (spleen), circulation, and heart in myocardial fibrosis secondary to hypertension remains limited. In this study, we characterized the interrelationship between monocyte/macrophage populations in the spleen, blood, and heart in a well-described model of hypertension.
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Key words
monocytes/macrophages,hypertension,heart,pro-inflammatory
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