Identität und physikochemische Eigenschaften von 1-(4-Chlorphenyl)-4-morpholino-imidazolin-2-on, AWD 131-138

The structure of the anticonvulsant 1-(4-chlorophenyl)-4-(4-morpholinyl)-2,5-dihydro-1H-imidazolin-2-one (Code: AWD 131-138, CAS-No.: 188116-07-6) was proved by IR, UV, 1 HNMR, 13 C NMR and mass spectra. AWD 131-138 is practically insoluble in a neutral aqueous medium at 20 °C (S ∼ 0.08 g/l). The solubility of the substance in 0.1 N HCl is about 2.7 g/l. In DMF, AWD 131-138 is sparingly soluble (S ∼ 28.5 g/l). The pK a -value is about 2.5. The partition coefficients P = C Octanol /C water at 37 °C range from 0.7 at pH ∼ 1 to about 20 at pH > 6.