P112 Discovery of a Novel, High Affinity, Small Molecule αvβ6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis
QJM: An International Journal of Medicine（2016）
摘要
Fibrosis is the formation of scar tissue due to injury or long-term inflammation and is a leading cause of morbidity and mortality in disorders that include IPF. The αvβ6 integrin has been identified as playing a key role in the activation of TGFβ that is hypothesized to be pivotal in …
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关键词
small molecule αvβ6 inhibitor,fibrosis
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