A Novel Hybrid Nano‐composite Grafted Electrochemically Reduced Graphene Oxide Based Sensor for Sensitive Determination of Efavirenz

A novel, facile fabrication, based on electrochemically reduced graphene oxide (ErGO), grafted with Pt nanoparticles and Nafion hybrid nano-composite (ErGO-Pt/Nafion) on the surface of edge plane pyrolytic graphite (EPPG) has been reported. The fabricated sensor has been used for the sensitive and selective determination of efavirenz (EFZ), a well-known drug for HIV infections. The ErGO-Pt/Nafion film was characterized by Field Emission Scanning Electron Microscopy (FE-SEM), Energy-dispersive X-ray spectrometry (EDS) and Electrochemical Impedance Spectroscopy (EIS). The experimental results reveal that the modified sensor displays an excellent electrocatalytic activity towards the oxidation of EFZ and exhibits a large linear dynamic relationship in the range of 0.05M to 150M, with a detection limit of 1.8nM. Practical utility of the developed sensor has been demonstrated by determining the EFZ in biological fluids and pharmaceutical samples and a low detection limit with high sensitivity observed makes it valuable for the clinical diagnosis.