Leukapheresis を行った Hyperleukocytic Acute Leukemia の2例

We performed leukapheresis in combination with chemotherapy in 2 cases of acute leukemia in which the white blood cell count showed greater than 300, 000/μl.As a result of this treatment, a case (AMOL) achieved complete remission in spite of the complication of cerebral bleeding, but the other case (AML) failed to achieve complete remission due to severe cerebral thrombosis. As one of the reasons for complete remission, we think that the leukapheresis had inhibited the progression of cerebral bleeding before chemotherapy became effective. The white blood cell count decreased promptly after the administration of chemotherapy in both cases. From these cases, we suggest that the combination of leukapheresis and chemotherapy is useful for severe hyperleukocytic acute leukemia.