EP-1420: Cyberknife® radiotherapy for recurrent or oligometastatic tumours in children and adolescents

ESTRO 35 2016 _____________________________________________________________________________________________________ epidemiological study, and will be used to test the validity of a predictive risk model based on values of neutron RBE which will be derived from the physics task in the ANDANTE project. Based on the experience from the feasibility study at LLUMC, a proposal for a prospective epidemiological study using pediatric proton therapy data collected from multiple proton centers world-wide is prepared. For this purpose, published results of epidemiological studies on second malignant neoplasms (SMN) after radiotherapy in childhood are reviewed. Up to now, 57 papers were identified from 2001 until present with the objective to estimate the magnitude of the effect of radiation exposure on the occurrence of SMN. Furthermore, European proton therapy centers were contacted in order to assess the feasibility of creating a prospective database on pediatric patients. Five out of thirteen proton therapy centers already replied, showing great interest in preliminary participation in discussion on forming a future prospective study.