One‐pot synthesis of 3,4‐dihydropyridin‐2‐ones via tandem reaction of Blaise reaction intermediate and acrylic ester
APPLIED ORGANOMETALLIC CHEMISTRY(2016)
Abstract
An efficient method for the synthesis 3,4-dihydropyridin-2-ones has been developed via tandem one-pot Michael-type addition and cyclization of the Blaise reaction intermediate and acrylic ester. A series of readily available nitriles, bromoacetic esters and acrylic esters have been employed to examine the scope of substrates for this method. Copyright (C) 2015 John Wiley & Sons, Ltd.
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Key words
zinc,3,4-dihydropyridin-2-ones,Blaise reaction,one-pot synthesis
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