EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through β-catenin/ID2 pathway

•EYA4 gene functioned as a novel tumor suppressor gene in PDAC cells.•EYA4 exerted its biological functions on PDAC cells in an ID2-dependent manner.•EYA4 repressed ID2 expression via blocking β-catenin nuclear translocation mediated by β-catenin Ser675 dephosphorylation.•EYA4 expression was an independent prognostic molecular marker for pancreatic ductal adenocarcinoma.