One-pot multicomponent asymmetric synthesis of α -amidosulfides from thiophenol and N -acylimines generated in situ from α -amidosulfones

A novel one-pot, multicomponent asymmetric synthesis of α -amidosulfides was described. By employing chiral phosphoric acid as Brønsted acid and catalyst, α -amidosulfides were obtained in excellent yields with high to excellent enantioselectivities via reaction of thiophenol and N -acylimines generated in situ from α -amidosulfones. Graphical abstract