Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner

•Effect of DHC on NFIA, NF-κB and inflammatory cytokines expression.•Negative effect of NFIA on NF-κB and inflammatory cytokines expression.•Role of NFIA and NF-κB in DHC-induced proinflammatory response.•DHC may be a promising candidate as an anti-inflammatory drug for atherosclerosis as well as other inflammatory diseases.