Effect Of Age At Onset On Disease Activity And Clinical Features In Patients With Primary Sjogren'S Syndrome

Background Primary Sjogren9s syndrome (pSS) is an autoimmune disease characterized by lymphocyte infiltration in exocrine glands. Although most of the patients developed the disease in middle age, there are younger onset patients. Objectives To examine relationship between age at onset and clinical features including disease activity in patients with pSS. Methods Clinical data of 75 women with pSS who visited our hospital from Aug. 2010 to Dec. 2014 were collected from medical charts. Of them, ESSPRI 1 and ESSDAI 2 were assessed in 72 and 71 patients, respectively. Results Average age, age at onset, and duration of disease were 60.9±12.6, 48.3±13.9, and 12.8±7.3 years, respectively. Number of patients with low (ESSDAI Conclusions Younger onset pSS patients had higher disease activity than middle age or elderly onset patients. Severity of fatigue and lymphadenopathy were the clinical characteristics in younger onset pSS. References Seror R, et al. Ann Rheum Dis 2011; 70:968-72. doi: 10.1136/ard.2010.143743 Seror R, et al. Ann Rheum Dis 2010;69:1103-9. doi: 10.1136/ard.2009.110619 Disclosure of Interest None declared