Single-Electron Transmetalation: Photoredox/Nickel Dual Catalytic Cross-Coupling of Secondary Alkyl β‑Trifluoro­borato­ketones and -esters with Aryl Bromides

The first cross-coupling of secondary alkyl β-trifluoro­borato­ketones and -esters has been achieved through application of photoredox/nickel dual catalysis. Although the related β-trifluoro­borato­amides have been effectively cross-coupled via Pd-catalysis, the corresponding ketones and esters had proven recalcitrant prior to this report. Reactions occur under mild conditions, and a variety of functional groups and sterically and electronically diverse reaction partners are tolerated.