HPLC fingerprint of Qigu Capsules
Chinese traditional and herbal drugs(2014)
Abstract
Objective To establish the HPLC fingerprint of Qigu Capsules for its quality control. Methods Platisil-C18 column(250 mm × 4.6 mm, 5 μm) was used with acetonitrile-methanol-water in gradient elution mode. The detective wavelength was 270 nm, the column temperature was set at 30 ℃, and the flow rate was 1.0 mL/min. Results Fingerprints of 15 batches of Qigu Capsules were established and 16 common peaks were identified, 15 of which belonged to herbs. The similarity was more than 0.9. Eight chemical compounds were identified by comparing the reference substance with UFLC-ESI-MS/MS. Sixteen samples were classified into three groups based on cluster analysis. Conclusion The method can be used for the quality control of Qigu Capsules with good precision, accuracy, and reproducibility.
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Key words
hplc fingerprint
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