Single cell genotyping of exome sequencing-identified mutations to characterize the clonal composition and evolution of inv(16) AML in a CBL mutated clonal hematopoiesis

Christoph Niemöller,Nathalie Renz,Sabine Bleul,Nadja Blagitko-Dorfs,Christine Greil,Kenichi Yoshida,Dietmar Pfeifer,Marie Follo,Justus Duyster,Rainer Claus,Seishi Ogawa,Michael Lübbert,Heiko Becker

Leukemia Research（2016）

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摘要

•Genetics provide insights into evolution of inv(16) AML in CBL mutated hematopoiesis.•Single cell genotyping verifies clonal architecture derived from bulk genetic analyses.•Mutated PTPRT may contribute to inv(16) AML at later stage by enhancing proliferation.

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关键词

AML,inv(16),CBL,PTPRT,Single cell,Clonal hematopoiesis

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