Soluble Epoxide Hydrolase Inhibitor Through Peroxisome Proliferator Activated Receptorγ Regulating Endothelial Progenitor Cells' Function

Aim To observe the effect and mechanism of soluble epoxide hydrolase inhibitor t-AUCB regulating murine endothelial progenitor cellsu0027 function. Methods Separated by density gradient centrifugation to obtain mouse bone marrow progenitor cells,different concentrations of t-AUCB and peroxisome proliferator activated receptorγ( PPARγ)blocker GW9662 pre-intervented endothelial progenitor cells,after that endothelial progenitor cell proliferation,adhesion,migration,angiogenesis ability were detected in vitro. Results From 0 ~ 100 μmol / L,as the concentration increases,t-AUCB can increase endothelial progenitor cell proliferation,adhesion,migration,angiogenesis ability in vitro. Conclusion Soluble epoxide hydrolase inhibitor t-AUCB involved in forward regulating endothelial progenitor cellu0027function,and its function is associated with activation of PPARγ on endothelial progenitor cell.