Analysis between expression of topoisomerase IIα and sensitivity of epirubicin in patients with breast cancer

Objective To explore the expression of TopoⅡα and the relationship between the expression of TopoⅡα and the response to anthracycline-containing first-line regimens in Breast carcinoma. Methods By using immunohistochemical method,the expression and Clinical significance were detected in 63 cases of breast carcinoma.Results In breast carcinoma tissues,the positive expression rate of TopoⅡαwas 73.0%.The expression of TopoⅡαwas associated with Her-2(P=0.026),but the expression of TopoⅡα in the patients' age,tumor size,site,lymph node metastasis,ER and PR was not significant(P 0.05). The effective rate of TopoⅡαpositive expression applying anthracene ring chemotherapy drugs was 3.077 times than TopoⅡα negative expression(P=0.032).The time to progression of the group of TopoⅡα positive expression was significantly longer than the group of TopoⅡαnegative expression. Conclusion The expression of TopoⅡα in Breast carcinoma contributes to the selection of drug in chemotherapy and prognosis evalation of breast cancer.