通腑清降法对骨创伤合并感染患者SIRS/CARS平衡调控作用的研究

Fengying WANG,Tiezhu YANG,Lili YOU,Songlin MING,Liangye LI

Chinese Journal of Traditional Medical Science and Technology（2015）

Cited 23|Views0

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Abstract

目的:观察通腑清降法组方的通腑净化汤对骨创伤合并感染后SIRS/CARS失衡状态的调控作用.方法:300例患者随机平均分入中药组和对照组,中药组采用通腑净化汤和西医常规治疗,对照组仅采用西医常规治疗,观察治疗前和治疗后第3、7天外周血炎性因子和T细胞亚群的变化,以及治疗后7天患者临床症状改善情况.结果:治疗后7天,中药组患者临床症状改善明显,总疗效明显优于对照组(P＜0.05);治疗后3天、7天,与对照组比较,治疗组TNF-α、IL-6、IL-10水平明显降低(P＜0.05),CD4+以及CD;/CD8+比值升高.结论:通腑净化汤联合西医常规治疗骨创伤合并感染后SIRS/CARS失衡状态,能有效减少炎症介质产生,抑制炎症反应,调节免疫功能,调控SIRS/CARS平衡.

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Key words

infection after bone trauma,Tongfu Jinghua Tang,Tongfu Qingjiang method,T lymphocyte subgroup,IL-6,IL-10,TNF-α

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