Chemotherapy for Advanced Head and Neck Cancer with CDDP, Peplomycin and MTX.

A group study of chemotherapy for advanced head and neck cancer using CDDP, Peplomycin (or Bleomycin) and MTX was carried out at the Head and Neck devisions of 14 cancer centers in Japan. 136 cases were registered from Oct. '84 to Mar. '86. These cases were devided in to two regimens as is seen in the following methods. Regimen ACDDP 80 mg/m2 i.v. (day 1) PEP 15 mg/m2 s.c. infusion or IVH (day 2 to 5) MTX 40 mg/m2 i.v. (day 2)Regimen B CDDP 80 mg/body i.v. (day 4) BLM 15 mg/body i.v. (day 1, 15) MTX 20 mg/body i.v. (day 1, 5) every 3 weeks /course